Targeted Peptide Discovery Technology Service-Tekbiotech-Yeast Display Service,Phage display technology

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Targeted Peptide Discovery Technology Service

Based on its experienced phage surface display technology, TekBiotech provides targeted peptide discovery services to global customers. Different from the well-known recombinant M13 phage display technology, the M13 peptide surface display technology provided by TekBiotech is to modify the wild-type M13 phage and insert the random peptide sequence into the N-terminus of the P3 protein of the wild-type M13 phage through gene editing engineering, so that the random peptide is displayed on the surface of the wild-type M13 phage along with the expression of the coat protein, and then the targeted peptide is screened through a simple blue-white screening system.

█ Targeted Peptide Development Service Based On Phage Display Technology

TekBiotech adopts modular design principles and provides customers with a very convenient service form: customers can customize each module at will and choose any module to start the project, as shown in Figure 1, the different modules of the M13 phage display system:

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Figure1 M13 phage targeted peptide development process based on phage technology platform

Therefore, TeKBiotech's targeted peptide development technology includes:

Cyclic peptide display library construction service

Linear peptide display library construction service

Bicyclic peptide library display library construction service

In vitro peptide screening technology service

In vivo animal screening technology service

█ Targeted Peptide Discovery Technology Platform Service Advantages

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Short development cycle: 2-3 weeks

(pre-made peptide library)

Low false positive, blue-white system, no

need for auxiliary phage and ELISA

verification

Large library capacity, high

screening success rate

Flexible library screening methods: solid phase

screening, liquid phase screening, cell screening,

in vivo screening

Targeted Peptide Discovery Technology Service Frequently Asked Questions

What is Targeted Peptide Discovery Technology?

Targeted peptide discovery technology is a technique to discover biologically active peptide molecules by screening for short peptide sequences that bind to specific targets (e.g., receptors, enzymes, proteins, or pathogens). These peptide molecules are able to bind highly specifically to the target and thus play an important role in areas such as disease treatment, targeted drug delivery, diagnostics and vaccine development. Targeted peptides can be screened from multiple peptide libraries by biomolecular recognition techniques, chemical synthesis, library screening, and so on. Through targeted peptide discovery technology, researchers can obtain high-affinity peptides for specific targets, thereby optimizing their pharmacological properties and increasing their potential for clinical application.
What are the application areas of targeted peptide discovery technology?

Targeted peptide discovery technology is widely used in drug discovery, diagnostics, vaccine research, targeted therapy and biomarker discovery. In drug development, targeted peptides can be used as drug candidates to exert pharmacological effects by combining with specific targets; in targeted therapy, targeted peptides can be used in the precise treatment of tumors, infections, and other diseases, delivering drugs directly to the focal site and reducing the impact on normal tissues; in diagnostics, targeted peptides can be used as biomarkers for the early detection of diseases; in vaccine development, targeted peptides can be used for the design of immune responses against specific pathogens. In vaccine development, targeted peptides can be used to design immune responses against specific pathogens. With the rapid development of precision medicine and personalized therapy, the application of targeted peptides is becoming more and more promising.
What are the core methods of targeted peptide discovery technology?

The core methods of targeted peptide discovery technology mainly include peptide library screening, synthetic chemistry and bioanalytical methods. Peptide library screening usually adopts phage display, yeast display and other display technologies, by displaying peptide libraries on the surface of microorganisms, combined with the target molecules for screening, to find peptides with strong binding affinity to the target; chemical synthesis methods through the solid-phase synthesis or liquid-phase synthesis technology, rapid construction of peptide sequences and structural optimization; bio-analytical methods, including surface plasmon resonance (SPR), fluorescence polarization (FP), and Bioanalytical methods include Surface Plasmon Resonance (SPR), Fluorescence Polarization (FP) and ELISA, which are used to determine the binding affinity and kinetic properties of the peptide and the target. Through the combination of these methods, the discovery and optimization of target peptides can be carried out efficiently.
How to screen target peptides?

Screening of target peptides is usually realized by display library techniques (e.g. phage display, yeast display, etc.). First, the synthesized peptide library is displayed on the surface of microorganisms, one peptide per microorganism. Then, those peptide sequences that bind most strongly to the target (e.g., a specific receptor, enzyme, or protein) are selected by binding to the target. Through multiple rounds of screening, peptides with high affinity to the target can be accurately selected from a large peptide library. Further, the affinity and specificity of the screened peptides are evaluated using techniques such as surface plasmon resonance (SPR) and enzyme-linked immunosorbent assay (ELISA) to ensure their effectiveness and stability in subsequent applications.
How does the targeted peptide discovery technology integrate with drug development?

Targeted peptide discovery technology combined with drug development can be used to rapidly screen peptide molecules with drug potential as the basis for drug candidates. Targeted peptides can be used as an alternative or complement to antibody drugs, vaccines, or even as carriers in drug delivery systems. For example, through the selection and optimization of targeting peptides, it is possible to design drug carriers with high affinity and selectivity for precise drug delivery and improved therapeutic effects. Targeted peptides can also be used as binders for small molecule drugs to enhance their selectivity and efficacy. In addition, targeted peptides are able to be used as a cutting-edge technology for drug development in areas such as tumor therapy, immunomodulation, and anti-infection therapy.

What is Targeted Peptide Discovery Technology?

Targeted peptide discovery technology is a technique to discover biologically active peptide molecules by screening for short peptide sequences that bind to specific targets (e.g., receptors, enzymes, proteins, or pathogens). These peptide molecules are able to bind highly specifically to the target and thus play an important role in areas such as disease treatment, targeted drug delivery, diagnostics and vaccine development. Targeted peptides can be screened from multiple peptide libraries by biomolecular recognition techniques, chemical synthesis, library screening, and so on. Through targeted peptide discovery technology, researchers can obtain high-affinity peptides for specific targets, thereby optimizing their pharmacological properties and increasing their potential for clinical application.
What are the application areas of targeted peptide discovery technology?

Targeted peptide discovery technology is widely used in drug discovery, diagnostics, vaccine research, targeted therapy and biomarker discovery. In drug development, targeted peptides can be used as drug candidates to exert pharmacological effects by combining with specific targets; in targeted therapy, targeted peptides can be used in the precise treatment of tumors, infections, and other diseases, delivering drugs directly to the focal site and reducing the impact on normal tissues; in diagnostics, targeted peptides can be used as biomarkers for the early detection of diseases; in vaccine development, targeted peptides can be used for the design of immune responses against specific pathogens. In vaccine development, targeted peptides can be used to design immune responses against specific pathogens. With the rapid development of precision medicine and personalized therapy, the application of targeted peptides is becoming more and more promising.
What are the core methods of targeted peptide discovery technology?

The core methods of targeted peptide discovery technology mainly include peptide library screening, synthetic chemistry and bioanalytical methods. Peptide library screening usually adopts phage display, yeast display and other display technologies, by displaying peptide libraries on the surface of microorganisms, combined with the target molecules for screening, to find peptides with strong binding affinity to the target; chemical synthesis methods through the solid-phase synthesis or liquid-phase synthesis technology, rapid construction of peptide sequences and structural optimization; bio-analytical methods, including surface plasmon resonance (SPR), fluorescence polarization (FP), and Bioanalytical methods include Surface Plasmon Resonance (SPR), Fluorescence Polarization (FP) and ELISA, which are used to determine the binding affinity and kinetic properties of the peptide and the target. Through the combination of these methods, the discovery and optimization of target peptides can be carried out efficiently.
How to screen target peptides?

Screening of target peptides is usually realized by display library techniques (e.g. phage display, yeast display, etc.). First, the synthesized peptide library is displayed on the surface of microorganisms, one peptide per microorganism. Then, those peptide sequences that bind most strongly to the target (e.g., a specific receptor, enzyme, or protein) are selected by binding to the target. Through multiple rounds of screening, peptides with high affinity to the target can be accurately selected from a large peptide library. Further, the affinity and specificity of the screened peptides are evaluated using techniques such as surface plasmon resonance (SPR) and enzyme-linked immunosorbent assay (ELISA) to ensure their effectiveness and stability in subsequent applications.
How does the targeted peptide discovery technology integrate with drug development?

Targeted peptide discovery technology combined with drug development can be used to rapidly screen peptide molecules with drug potential as the basis for drug candidates. Targeted peptides can be used as an alternative or complement to antibody drugs, vaccines, or even as carriers in drug delivery systems. For example, through the selection and optimization of targeting peptides, it is possible to design drug carriers with high affinity and selectivity for precise drug delivery and improved therapeutic effects. Targeted peptides can also be used as binders for small molecule drugs to enhance their selectivity and efficacy. In addition, targeted peptides are able to be used as a cutting-edge technology for drug development in areas such as tumor therapy, immunomodulation, and anti-infection therapy.

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