PROTAC Customization Services-Tekbiotech-Yeast and Phage Display CRO, Expert in Nano-body and Antibody Drug Development

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PROTAC Customization Services

TekBiotech is committed to providing customers with high-quality customized PROTAC services, including PROTAC design and synthesis, in vitro efficacy assays (e.g., target protein degradation and cell-killing assays in cells expressing the target at native or overexpressed levels), and in vivo efficacy evaluation in animal models, thereby offering robust support for customers’ subsequent development of therapeutic PROTACs.

TekBiotech has many years of project experience and expertise in PROTAC development. Through years of development, TekBiotech has established a comprehensive PROTAC development system, enabling it to provide clients with high-quality PROTAC drug discovery services targeting a variety of targets (primarily disease-related targets, such as kinases, nuclear receptors, and “undruggable” transcription factors).

图1 PROTAC分子作用原理图.png

Figure 1: Schematic diagram illustrating the mechanism of action of PROTAC molecules

█ PROTAC Customization Services

The PROTAC customization service is based on the selection, design, and chemical synthesis of the POI (protein of interest, i.e., the target protein) ligand, the linker, and the E3 ubiquitin ligase ligand. Specifically, a known POI ligand (primarily known agonists and inhibitors of the target protein) is chemically linked to an E3 ubiquitin ligase ligand (most commonly a ligand of CRBN or VHL) via a suitable linker. PROTACs designed and synthesized by TekBiotech have been shown to effectively induce target protein degradation.

For specific targets (e.g., those without known ligands), scientists at TekBiotech evaluate the target sequence and synthesize the target protein. Using peptide or aptamer screening platforms, they identify peptides or nucleic acid aptamers that bind the target protein and design an optimal PROTAC synthesis strategy.

█ Types of PROTAC Customization Services

TekBiotech has accumulated extensive project experience in the development of PROTACs targeting disease targets such as kinases, nuclear receptors, and “undruggable” transcription factors. Based on our clients’ needs, we have categorized these PROTACs into the following types, as shown in Table 1:

Small-Molecule PROTAC Development Services

Peptide PROTAC Development Services

Nucleic Acid-Based PROTAC Development Services

TekBiotech also offers customized PROTAC design and synthesis services tailored to specific customer needs (e.g., ternary PROTAC design and synthesis).

█ Advantages of PROTAC Customization Services


A wide range of target proteins to choose from: kinases, nuclear receptors, “undruggable” transcription factors, and more	One-stop solution: comprehensive services ranging from design and synthesis to in vitro and in vivo testing	Comprehensive characterization and analysis: molecular-level analysis, cellular-level analysis, and in vivo analysis	Mature downstream detection platform: cell-based efficacy assays, in vivo efficacy evaluation

Traceable experimental records: experimental reports in Chinese and English, original experimental records	Custom PROTAC design: diverse PROTAC design and synthesis options (e.g., ternary PROTACs)	A variety of E3 ubiquitin ligase ligands are available: CRBN, VHL, etc.	A variety of linkers are available (PEG chains, alkyl chains, rigid chains [including aromatic rings, piperazine, etc.], and others)